Advancing nucleic acid delivery through cationic polymer design: non-cationic building blocks from the toolbox
Ilaria Porello, Nina Bono, Gabriele Candiani, Francesco Cellesi
Abstract
The rational integration of non-cationic building blocks into cationic polymers can be devised to enhance the performance of the resulting gene delivery vectors, improving cell targeting behavior, uptake, endosomal escape, toxicity, and transfection efficiency.
Topics & Concepts
Cationic polymerizationNucleic acidToolboxChemistryPolymerComputer sciencePolymer chemistryBiochemistryOrganic chemistryProgramming languageRNA Interference and Gene DeliveryAdvanced biosensing and bioanalysis techniquesDNA and Nucleic Acid Chemistry