G-Quadruplex DNA as a Target in Pathogenic Bacteria: Efficacy of an Extended Naphthalene Diimide Ligand and Its Mode of Action
Rubén Cebrián, Efres Belmonte‐Reche, Valentina Pirota, Anne de Jong, Juan Carlos Morales, Mauro Freccero, Filippo Doria, Oscar P. Kuipers
Abstract
, a different action mechanism was described for Gram-positive or negative bacteria. This asymmetric activity profile could be related to the different prevalence of putative G4-DNA structures in each group, the influence that they can exert on gene expression, and the different roles of the G4 structures in these bacteria, which seem to promote transcription in Gram-positive bacteria and repress transcription in Gram-negatives.
Topics & Concepts
PharmacophoreBacteriaChemistryDNATranscription (linguistics)EpigeneticsMode of actionMechanism of actionGeneMicrobiologyCell biologyBiochemistryGeneticsBiologyIn vitroLinguisticsPhilosophyDNA and Nucleic Acid ChemistryAdvanced biosensing and bioanalysis techniquesBacteriophages and microbial interactions