Integrated Phenotypic and Transcriptomic Analyses of Osteoporosis in Type 2 Diabetic Mice
Shu‐Juan Xing, Ying-Feng Gao, Lu Liu, Bing‐Dong Sui, Ning-Ning Da, Jinyu Liu, Hao Wang, Yuan Yuan, Yuan Qin, Peisheng Liu, Si-Qi Ying, Kai Zhang, Jie-Xi Liu, Xi Chen, Yihan Liu, Xin Xie, Yan Jin, Sha Zhang, Chenxi Zheng
Abstract
These findings elucidate the bone lesion phenotype in T2D, particularly at the early phase, uncover changes in gene expression profiles of bone during T2D progression, and clarify the functional alterations in bone stem cells, providing a basis for subsequent research and the development of treatment strategies.
Topics & Concepts
PhenotypeOsteoporosisTranscriptomeType 2 diabetesBiologyMedicineInternal medicineDiabetes mellitusGeneticsEndocrinologyGeneGene expressionBone Metabolism and DiseasesBone and Dental Protein StudiesBone health and osteoporosis research