α‐Difluoroalkylation of Benzyl Amines with Trifluoromethylarenes
Wen‐Jun Yue, Rubén Martı́n
Abstract
An α-difluoroalkylation of benzyl amines with trifluoromethylarenes is disclosed herein. This protocol is characterized by its operational simplicity, excellent chemoselectivity and broad scope-even with advanced synthetic intermediates-, thus offering a new entry point to medicinally-relevant α-difluoroalkylated amines from simple, yet readily accessible, precursors.
Topics & Concepts
ChemoselectivityScope (computer science)SimplicityCombinatorial chemistryProtocol (science)ChemistrySimple (philosophy)Computer scienceOrganic chemistryCatalysisMedicineProgramming languagePhilosophyEpistemologyPathologyAlternative medicineFluorine in Organic ChemistrySynthesis and Reactions of Organic CompoundsInorganic Fluorides and Related Compounds