A naturally occurring FXR agonist, alisol B 23-acetate, protects against renal ischemia-reperfusion injury
Zhi‐Lin Luan, Wenhua Ming, Xiaowan Sun, Cong Zhang, Yang Zhou, Feng Zheng, Yongliang Yang, Youfei Guan, Xiaoyan Zhang
Abstract
In the present study, we found that alisol B 23-acetate (ABA), an identified natural farnesoid X receptor (FXR) agonist from the well-known traditional Chinese medicine Alismatis rhizoma, protects against ischemic acute kidney injury (AKI) in an FXR-dependent manner, as reflected by improved renal function, reduced renal tubular apoptosis, ameliorated oxidative stress, and suppressed inflammatory factor expression. Therefore, ABA may have great potential as a novel therapeutic agent in the treatment of AKI in the future.
Topics & Concepts
Farnesoid X receptorAgonistPharmacologyKidneyChemistryReperfusion injuryReceptorKnockout mouseRenal ischemiaNuclear receptorIschemiaMedicineInternal medicineBiochemistryTranscription factorGeneDrug Transport and Resistance MechanismsPharmacological Effects and Toxicity StudiesTrace Elements in Health