Palladium-Catalyzed Annulative Coupling of Spirovinylcyclopropyl Oxindoles with <i>p</i>-Quinone Methides
Bijoy Debnath, Tanumay Sarkar, Pallab Karjee, Siddhartha K. Purkayastha, Ankur K. Guha, Tharmalingam Punniyamurthy
Abstract
Pd-catalyzed annulative coupling of spirovinylcyclopropyl oxindoles with p -quinone methides has been accomplished via cascade carbon–carbon bond formation to afford bis -spirooxindole scaffolds. The mild reaction conditions, diastereoselectivity, functional group diversity, post-synthetic transformations, and mechanistic studies using DFT calculations are the important practical features.
Topics & Concepts
PalladiumCatalysisQuinoneCoupling (piping)ChemistryCascadeCombinatorial chemistryFunctional groupComputational chemistryStereochemistryOrganic chemistryMaterials scienceMetallurgyChromatographyPolymerSynthesis of Indole DerivativesCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques