Chronic intermittent hypoxia enhances glycinergic inhibition in nucleus tractus solitarius
Shuping Jia, Nataliya Rybalchenko, Kishor Kunwar, George E. Farmer, Joel T. Little, Glenn M. Toney, J. Thomas Cunningham
Abstract
Chronic intermittent hypoxia (CIH) has been used to mimic the hypoxemia associated with sleep apnea and determine how these hypoxemias influence neural function. The nucleus of the solitary tract is the main site for chemoreceptor input to the CNS, but how CIH influences NTS inhibition has not been determined. These studies show that CIH increases glycine-mediated miniature IPSCs through mechanisms that depend on protein trafficking and astrocyte activation.
Topics & Concepts
Glycine receptorInhibitory postsynaptic potentialExcitatory postsynaptic potentialNeuroscienceGABAergicAstrocyteNeurotransmissionStrychninePatch clampChemistryPostsynaptic CurrentDigastric muscleGlycineBiologyReceptorElectrophysiologyAnatomyCentral nervous systemBiochemistryAmino acidNeuroscience of respiration and sleepObstructive Sleep Apnea ResearchSleep and Wakefulness Research