ATP6V0d2 Suppresses Alveoli Macrophage Alternative Polarization and Allergic Asthma via Degradation of PU.1
Na Liu, Yuchen Feng, Huicheng Liu, Wenliang Wu, Yuxia Liang, Pingfei Li, Zhengping Wei, Min Wu, Zhao-Hui Tang, Junyan Han, Xiang Cheng, Zheng Liu, Arian Laurence, Huabin Li, Guohua Zhen, Xiang‐Ping Yang
Abstract
PURPOSE: Macrophages are important regulators of environmental allergen-induced airway inflammation and asthma. ATP6V0d2 is a subunit of vacuolar ATPase highly expressed in macrophages. However, the functions of ATP6V0d2 in the regulation of pathogenesis of allergic asthma remain unclear. The aim of this study is to determine the function and related molecular mechanisms of macrophage protein ATP6V0d2 in allergic asthma. METHODS: with disease severity among asthmatic patients. RESULTS: expression was positively associated with disease severity. CONCLUSIONS: Our results identify macrophage Atp6v0d2, as an induced feedback inhibitor of asthma disease severity by promoting Pu.1 lysosomal degradation, which may in turn leads to reduced AAM polarization and Ccl17 production.