Discovery and SAR Evolution of Pyrazole Azabicyclo[3.2.1]octane Sulfonamides as a Novel Class of Non-Covalent <i>N</i>-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) Inhibitors for Oral Administration
Paolo Di Fruscia, Anna Carbone, Giovanni Bottegoni, Francesco Berti, Francesca Giacomina, Stefano Ponzano, Chiara Pagliuca, Annalisa Fiasella, Daniela Pizzirani, José Antonio Ortega, Andrea Nuzzi, Glauco Tarozzo, Luisa Mengatto, Roberta Giampà, Ilaria Penna, Debora Russo, Elisa Romeo, Maria Summa, Rosalia Bertorelli, Andrea Armirotti, Sine Mandrup Bertozzi, Angelo Reggiani, Tiziano Bandiera, Fabio Bertozzi
Abstract
could be regarded as a promising pharmacological tool to be further investigated in the field of inflammatory conditions.
Topics & Concepts
ChemistryAmidaseSulfonamidePyrazoleOctanePalmitoylethanolamideIn vivoPharmacologyStereochemistryEnzymeBiochemistryOrganic chemistryAntagonistBiologyBiotechnologyMedicineCannabinoid receptorReceptorBerberine and alkaloids researchCannabis and Cannabinoid ResearchDrug-Induced Hepatotoxicity and Protection