Analysis and Management of Rituximab Resistance in PLA2R1-Associated Membranous Nephropathy
Maxime Teisseyre, Sonia Boyer‐Suavet, Marion Crémoni, Vesna Brglez, Vincent Esnault, Barbara Seitz‐Polski
Abstract
Primary membranous nephropathy (pMN) is an autoimmune disease affecting kidney glomerulus and the most common cause of nephrotic syndrome (NS) in white adults without diabetes. The pathophysiology of pMN involves antibodies targeting podocyte antigens—mainly the M-type phospholipase A2 receptor (PLA2R1)—resulting in activation of the complement cascade.S1 The course of the disease is highly variable, ranging from spontaneous remission to progressive chronic kidney disease requiring renal replacement therapies.
Topics & Concepts
Membranous nephropathyMedicineRituximabNephrotic syndromeImmunologyGlomerulonephritisKidney diseaseComplement systemDiabetic nephropathyAntibodyKidneyInternal medicineRenal Diseases and GlomerulopathiesAutoimmune Bullous Skin DiseasesBiomedical Research and Pathophysiology