NAFLD indirectly impairs antigen-specific CD8+ T cell immunity against liver cancer in mice
John C. McVey, Benjamin L. Green, Benjamin Ruf, Justin McCallen, Simon Wabitsch, Varun Subramanyam, Laurence P. Diggs, Bernd Heinrich, Tim F. Greten, Chi Ma
Abstract
T cells but caused by accumulated macrophages in the liver environment. The findings suggest that targeting macrophages in NAFLD-driven HCC may improve therapeutic outcomes.
Topics & Concepts
AntigenImmunologyT cellImmunityCD8Immune systemCytotoxic T cellCancer researchBiologyAcquired immune systemFatty liverLiver cancerTumor antigenMedicineDiseaseImmunotherapyInternal medicineHepatocellular carcinomaIn vitroBiochemistryImmune Cell Function and InteractionLiver Disease Diagnosis and TreatmentEndoplasmic Reticulum Stress and Disease