Single-cell transcriptome profiling reveals β cell maturation in stem cell-derived islets after transplantation
Punn Augsornworawat, Kristina G. Maxwell, Leonardo Velazco-Cruz, Jeffrey R. Millman
Abstract
(Cell Reports 32, 108067-1–108067-13.e1–e6; August 25, 2020) In the originally published version of this article, Tables S4 and S6 contained incorrect gene labels. The corrected supplemental tables now appear with the article online. The authors regret this error. Single-Cell Transcriptome Profiling Reveals β Cell Maturation in Stem Cell-Derived Islets after TransplantationAugsornworawat et al.Cell ReportsAugust 25, 2020In BriefAugsornworawat et al. demonstrate that in vitro human stem-cell-derived islets have immature transcriptome profiles when compared to native human islets. After transplantation, immature SC-islet cells undergo drastic changes in transcriptome and acquire mature gene expression. Grafted SC-β cells express mature β cell genes, including MAFA and G6PC2, resembling native human islets. Full-Text PDF Open Access