COVID-19 vaccines induce severe hemolysis in paroxysmal nocturnal hemoglobinuria
Gloria F. Gerber, Xuan Yuan, Jia Yu, Benjamin A. Y. Cher, Evan M. Braunstein, Shruti Chaturvedi, Robert A. Brodsky
Abstract
Complement has emerged as a likely driver of the immune response and end-organ damage in COVID-19. 2] Thus, in vitro, the SARS-CoV-2 spike protein can convert an inactivator surface to an activator surface on nucleated cells.
Topics & Concepts
Paroxysmal nocturnal hemoglobinuriaComplement systemImmunologyHemolysisHemoglobinuriaMedicineImmune systemCD59VirologySARS-CoV-2 and COVID-19 ResearchComplement system in diseasesCOVID-19 Clinical Research Studies