Catabolic Ornithine Carbamoyltransferase Activity Facilitates Growth of Staphylococcus aureus in Defined Medium Lacking Glucose and Arginine
Itidal Reslane, Cortney R. Halsey, Amanda Stastny, Barbara Cabrera, Jongsam Ahn, Dhananjay Shinde, Madeline R. Galac, Margaret Sladek, Fareha Razvi, McKenzie K. Lehman, Kenneth W. Bayles, Vinai C. Thomas, Luke D. Handke, Paul D. Fey
Abstract
within the native arginine deiminase operon in addition to limited intracellular pools of ornithine. Surprisingly, approximately 50% of S. aureus clinical isolates can grow in media lacking arginine, suggesting that mutations are selected in S. aureus that allow growth in particular niches of the human host.
Topics & Concepts
Staphylococcus aureusArginineMicrobiologyOrnithine CarbamoyltransferaseCatabolismChemistryOrnithineBiochemistryArginaseBacteriaBiologyEnzymeAmino acidGeneticsAntimicrobial Resistance in StaphylococcusBacterial Genetics and BiotechnologyBacterial biofilms and quorum sensing