Photoredox-Catalyzed Sequential Decarboxylative/Defluorinative Aminoalkylation of CF<sub>3</sub>-Alkenes with <i>N</i>-Arylglycines
Hong Xin, Lu Zhang, Jinyi Liao, Xin‐Hua Duan, Yang Xu, Li‐Na Guo
Abstract
A photoredox-catalyzed sequential decarboxylative/defluorinative aminoalkylation of CF 3 -alkenes with N -arylglycines is described. This metal-free and redox-neutral protocol provided efficient access to the monofluoroalkenyl-1,5-diamines in good yields with excellent functional group compatibility. Mechanistic studies revealed that the reaction proceeds via a radical pathway with the gem -difluoroalkenyl amine as an intermediate.
Topics & Concepts
ChemistryCatalysisDecarboxylationMedicinal chemistryOrganic chemistryCombinatorial chemistryFluorine in Organic ChemistryInorganic Fluorides and Related CompoundsRadical Photochemical Reactions