Myeloid-derived suppressor cells deficient in cholesterol biosynthesis promote tumor immune evasion
Yu Chen, Yanquan Xu, Huakan Zhao, Yu Zhou, Jiangang Zhang, Juan Lei, Lei Wu, Mingyue Zhou, Jingchun Wang, Shuai Yang, Xiao Zhang, Guifang Yan, Yongsheng Li
Topics & Concepts
Cancer researchMyeloid-derived Suppressor CellReprogrammingCholesterolImmune systemmTORC1Liver X receptorProtein kinase BBiologyChemistryCell biologyCancerSuppressorSignal transductionImmunologyEndocrinologyInternal medicineMedicineNuclear receptorBiochemistryCellTranscription factorGeneImmune cells in cancerSphingolipid Metabolism and SignalingCholesterol and Lipid Metabolism