Roles of Two Major Domains of the Porcine Deltacoronavirus S1 Subunit in Receptor Binding and Neutralization
Yan Liu, Bin Wang, Qi-Zhang Liang, Fang-Shu Shi, Chun-Miao Ji, Xiao-Lian Yang, Yong-Le Yang, Pan Qin, Ruiai Chen, Yao-Wei Huang
Abstract
antibodies is partially attributed to blockage of sugar binding activity. Our findings further implicate PDCoV's great potential for interspecies transmission, and the data of receptor binding and neutralization may provide a basis for development of future intervention strategies.
Topics & Concepts
BiologyGlycoproteinVirologyAntibodyProtein subunitNeutralizationCoronavirusReceptorCell biologyGlycosylationViral entrySialic acidPlasma protein bindingMicrofold cellNeutralizing antibodyEpitopePeptide sequenceIntestinal epitheliumN-Acetylneuraminic acidHEK 293 cellsVirusBetacoronavirusBinding siteViral envelopeCell cultureMolecular biologyAmino acidBinding domainAminopeptidaseAnimal Virus Infections StudiesSARS-CoV-2 and COVID-19 ResearchPeptidase Inhibition and Analysis