Paclitaxel-loaded magnetic nanocrystals for tumor neovascular-targeted theranostics: an amplifying synergistic therapy combining magnetic hyperthermia with chemotherapy
Shuangyu Liu, Dongsheng Shi, Ling Chen, Yu Yan, Xingqi Wang, Yingying Song, Shengyan Pu, Yijun Liang, Yang Zhao, Yu Zhang, Jun Xie
Abstract
, 390 kHz), leading to an effective TMH effect. Subsequently, the TMH-mediated temperature elevation accelerated the PTX release from the inner lipid layer, promoting the synergetic thermo-chemotherapy in vivo. The amplifying synergistic treatment strategy obviously improved the anti-tumor efficacy of MNCs-PTX@RGD, and simultaneously increased the survival time of the mice to more than 46 days, which provided a broad development prospect in clinical applications.
Topics & Concepts
PaclitaxelHyperthermiaIn vivoMagnetic hyperthermiaMaterials scienceCancer researchChemotherapyMagnetic nanoparticlesMedicineNanotechnologyNanoparticleInternal medicineBiologyBiotechnologyNanoparticle-Based Drug DeliveryCharacterization and Applications of Magnetic NanoparticlesNanoplatforms for cancer theranostics