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Design, Synthesis, and Antimicrobial Evaluation of a New Series of <i>N</i>-Sulfonamide 2-Pyridones as Dual Inhibitors of DHPS and DHFR Enzymes

Rasha A. Azzam, Rasha E. Elsayed, Galal H. Elgemeie

2020ACS Omega76 citationsDOIOpen Access PDF

Abstract

is the most potent dual DHPS/DHFR inhibitor.

Topics & Concepts

DHPSDihydrofolate reductaseDihydropteroate synthaseChemistryEnzymeAntimicrobialSulfonamideStereochemistryBiochemistryBiologyOrganic chemistryPlasmodium falciparumMalariaPyrimethamineImmunologySynthesis and biological activityQuinazolinone synthesis and applicationsEnzyme function and inhibition
Design, Synthesis, and Antimicrobial Evaluation of a New Series of <i>N</i>-Sulfonamide 2-Pyridones as Dual Inhibitors of DHPS and DHFR Enzymes | Litcius