Retinal glial remodeling by FGF21 preserves retinal function during photoreceptor degeneration
Zhongjie Fu, Chenxi Qiu, Gaël Cagnone, Yohei Tomita, Shuo Huang, Bertan Cakir, Yumi Kotoda, William E. Allen, Edward Bull, James D. Akula, Jean‐Sébastien Joyal, Ann Hellström, Saswata Talukdar, Lois E. H. Smith
Abstract
was specifically expressed in Müller glia/astrocytes. Of all retinal cells, FGF21 predominantly affected genes in Müller glia/astrocytes with increased expression of axon development and synapse formation pathway genes. Therefore, enhancing retinal glial axon and synapse formation with neurons may preserve retinal function in RP and may suggest a general therapeutic approach for retinal degenerative diseases.
Topics & Concepts
Retinitis pigmentosaRetinalBiologyRetinal degenerationRetinaMuller gliaNeuroscienceRetinal regenerationNeuroprotectionCell biologyAxonNeurogliaPhotoreceptor cellCentral nervous systemStem cellProgenitor cellBiochemistryRetinal Development and DisordersPhotoreceptor and optogenetics researchRetinal Diseases and Treatments