The biothiol-triggered organotrisulfide-based self-immolative fluorogenic donors of hydrogen sulfide enable lysosomal trafficking
Sulendar K. Mahato, Debojit Bhattacherjee, Krishna P. Bhabak
Abstract
Biothiol-reactive organotrisulfide-based self-immolative fluorogenic donors of H2S are rationally designed for the efficient monitoring of intracellular and lysosomal trafficking of H2S with a concomitant turn-on fluorescence. The non-toxic nature of the donors with a sustained release of H2S will certainly be helpful for their biomedical applications in the future.
Topics & Concepts
ChemistryHydrogen sulfideSulfideCombinatorial chemistrySulfurOrganic chemistrySulfur Compounds in BiologyMolecular Sensors and Ion DetectionLuminescence and Fluorescent Materials