Sensing Nitric Oxide in Cells: Historical Technologies and Future Outlook
Bethany Almeida, Katherine E. Rogers, Okhil K. Nag, James B. Delehanty
Abstract
Nitric oxide (NO) is a critical cell signaling molecule with important roles in both normal cellular physiology and pathology. Over the past 20 years, multiple sensing modalities have been developed for the intracellular synthesis (endogenous) and release (exogenous) of NO. In this review, we survey the historical progression of NO sensing platforms, highlight the current state of the art, and offer a forward-looking view of how we expect the field of NO sensing to develop in the context of recent advances in bio-nanotechnology and nanoscale cellular biosensors.
Topics & Concepts
Nitric oxideContext (archaeology)NanotechnologyModalitiesIntracellularCell signalingData scienceNeuroscienceComputer scienceChemistryCell biologyBiologyMaterials scienceSignal transductionSociologyPaleontologySocial scienceOrganic chemistryNitric Oxide and Endothelin EffectsPhotoreceptor and optogenetics researchAnalytical Chemistry and Sensors