The landscape of combining immune checkpoint inhibitors with novel Therapies: Secret alliances against breast cancer
Federico Rebaudi, Fabiana De Franco, Rayan Goda, Valentina Obino, Giorgio Vita, Camilla Baronti, Eleonora Iannone, Francesca Pitto, Barbara Massa, Daniela Fenoglio, Camilla Jandus, Francesca Poggio, Piero Fregatti, Ombretta Melaiu, Matteo Bozzo, Simona Candiani, Federica Papaccio, Marco Greppi, Silvia Pesce, Emanuela Marcenaro
Abstract
This review focuses on the immune checkpoint inhibitors (ICIs) in the context of breast cancer (BC) management. These innovative treatments, by targeting proteins expressed on both tumor and immune cells, aim to overcome tumor-induced immune suppression and reactivate the immune system. The potential of this approach is the subject of numerous clinical studies. Here, we explore the key studies and emerging therapies related to ICIs providing a detailed analysis of their specific and combined use in BC treatment.