Nanomaterials for Anti-Infection in Orthopedic Implants: A Review
Junhao Sui, Yijin Hou, Mengchen Chen, Zhong Zheng, Xiangyu Meng, Lu Liu, Shicheng Huo, Shu Liu, Hao Zhang
Abstract
Postoperative implant infection is a severe complication in orthopedic surgery, often leading to implant failure. Current treatment strategies mainly rely on systemic antibiotic therapies, despite contributing to increasing bacterial resistance. In recent years, nanomaterials have gained attention for their potential in anti-infection methods. They exhibit more substantial bactericidal effects and lower drug resistance than conventional antimicrobial agents. Nanomaterials also possess multiple bactericidal mechanisms, such as physico-mechanical interactions. Additionally, they can serve as carriers for localized antimicrobial delivery. This review explores recent applications of nanomaterials with different morphologies in post-orthopedic surgery infections and categorizes their bactericidal mechanisms.