Anti‐MDA5‐associated dermatomyositis
Rajiv Gupta, Sunil Kumar, Peter Gow, Leon Chang, Linda Yen
Abstract
Anti-MDA5-associated dermatomyositis (MDA5-associated DM) is an uncommon presentation of idiopathic inflammatory myositis, typically amyopathic, associated with rapidly progressive, treatment refractory interstitial lung disease and poor prognosis, particularly in patients with concomitant rapidly progressive interstitial lung disease (RP-ILD). We report two cases of MDA5-associated DM with fatal outcome in one of the patients, despite 'aggressive triple therapy' for RP-ILD.
Topics & Concepts
MedicineDermatomyositisInterstitial lung diseaseMDA5MyositisConcomitantDermatologyRefractory (planetary science)LungInternal medicineChemistryBiochemistryAstrobiologyPhysicsGeneRNA interferenceRNAInflammatory Myopathies and DermatomyositisEosinophilic Disorders and SyndromesInterstitial Lung Diseases and Idiopathic Pulmonary Fibrosis