Chemical constituents and anti-inflammatory activity of the total alkaloid extract from Melodinus cochinchinensis (Lour.) Merr. and its inhibition of the NF-κB and MAPK signaling pathways
Meilian Yang, Yudan Wang, Zhifeng Fan, Qingwang Xue, Guy Sedar Singor Njateng, Yaping Liu, Jianxin Cao, Afsar Khan, Guiguang Cheng
Topics & Concepts
Anti-inflammatoryIn vivoPharmacologyAlkaloidChemistryIκBαNF-κBInflammationLipopolysaccharideWestern blotMAPK/ERK pathwayp38 mitogen-activated protein kinasesTraditional medicineSignal transductionBiochemistryMedicineBiologyImmunologyStereochemistryBiotechnologyGeneNatural product bioactivities and synthesisAlkaloids: synthesis and pharmacologyPhytochemical Studies and Bioactivities