A Facile Route to Pyrazolo[1,2‐a]cinnoline via Rhodium(III)‐catalyzed Annulation of Pyrazolidinoes and Iodonium Ylides
Zi Yang, Yi Zhou, Haigang Li, Jieni Lei, Pingping Bing, Binsheng He, Yaqian Li
Abstract
Abstract A rhodium(III)‐catalysed cascade C−H bond activation/intramolecular cyclization of pyrazolidiones with iodonium ylide has been described, leading to the formation of various pyrazolo[1,2‐a]cinnolines. Herein, iodonium ylide serves as a carbene precursor. This protocol exhibits good regioselectivity and high functional group tolerability under mild reaction conditions.
Topics & Concepts
YlideChemistryAnnulationRhodiumIntramolecular forceCarbeneRegioselectivityCinnolineCatalysisMedicinal chemistryCarbenoidCyclopropanationStereochemistryOrganic chemistryCatalytic C–H Functionalization MethodsCyclopropane Reaction MechanismsSynthesis and Catalytic Reactions