Application of CD38 monoclonal antibody in kidney disease
Zhiyi Chen, Qianchun Xu, Zhangfei Shou
Abstract
CD38 antigen is a glycoprotein that found on the surface of several immune cells, and this property makes its monoclonal antibodies have the effect of targeted elimination of immune cells. Therefore, the CD38 monoclonal antibody (such as daratumumab, Isatuximab) becomes a new treatment option for membranous nephropathy, lupus nephritis, renal transplantation, and other refractory kidney diseases. This review summarizes the application of CD38 monoclonal antibodies in different kidney diseases and highlights future prospects.
Topics & Concepts
Monoclonal antibodyDaratumumabCD38Lupus nephritisImmunologyMedicineImmune systemAntigenAntibodyKidneyDiseaseBiologyPathologyInternal medicineStem cellCD34GeneticsCytomegalovirus and herpesvirus researchRenal Diseases and GlomerulopathiesMonoclonal and Polyclonal Antibodies Research