Organoids in virology
Julie T. S. Chu, Mart M. Lamers
Abstract
To adequately prepare against imminent disease outbreaks from diverse and ever-changing viral pathogens, improved experimental models that can accurately recapitulate host-virus responses and disease pathogenesis in human are essential. Organoid platforms have emerged in recent years as amenable in vitro tools that can bridge the limitations of traditional 2D cell lines and animal models for viral disease research. We highlight in this review the key insights that have contributed by organoid models to virus research, the limitations that exist in current platforms, and outline novel approaches that are being applied to address these shortcomings.
Topics & Concepts
OrganoidVirologyBiologyDiseaseComputational biologyVirusViral pathogenesisHost (biology)Human diseaseNeuroscienceMedicineViral replicationGeneticsPathologyVirus-based gene therapy researchRespiratory viral infections researchSingle-cell and spatial transcriptomics