Design, synthesis and evaluation of the Brigatinib analogues as potent inhibitors against tertiary EGFR mutants (EGFRdel19/T790M/C797S and EGFRL858R/T790M/C797S)
Haotian Fang, Yingming Wu, Qitao Xiao, Dongbo He, Tongrui Zhou, Wenzhong Liu, Chunhao Yang, Yuli Xie
Topics & Concepts
T790MOsimertinibPharmacologyEpidermal growth factor receptorEGFR inhibitorsKinaseCancer researchMutantMedicineChemistryCancerGefitinibErlotinibInternal medicineBiochemistryGeneLung Cancer Treatments and MutationsQuinazolinone synthesis and applicationsCancer therapeutics and mechanisms