Monoethanolamine-induced glucose deprivation promotes apoptosis through metabolic rewiring in prostate cancer
Chakravarthy Garlapati, Shriya Joshi, Ravi Chakra Turaga, Manjari Mishra, Michelle D. Reid, Shobhna Kapoor, Liana Artinian, Vincent Rehder, Ritu Aneja
Abstract
: We provide the first evidence that Etn alters GLUT1 trafficking leading to metabolic stress in PCa. By upregulating phosphatidylethanolamine (PE), Etn modulates membrane fluidity and affects mitochondrial structure and function. Etn also induces autophagy in PCa cells, thereby promoting apoptosis. These data strongly suggest that Etn rewires cellular bioenergetics and could serve as a promising anticancer agent for PCa.
Topics & Concepts
GLUT1Glucose transporterChemistryAutophagyApoptosisCell biologyGlucose uptakeDownregulation and upregulationGLUT4InternalizationBiochemistryBiologyEndocrinologyCellInsulinGeneAutophagy in Disease and TherapyCancer, Hypoxia, and MetabolismLipid metabolism and biosynthesis