Cytotoxic auranofin analogues bearing phosphine, arsine and stibine ligands: A study on the possible role of the ligand on the biological activity
Ester Giorgi, Michele Mannelli, Tania Gamberi, M. Durante, Chiara Gabbiani, Damiano Cirri, Alessandro Pratesi
Abstract
)], have been synthesized and characterized. The nature of the ligand has been modified by moving down among some of the elements of group 15, i.e. phosphorus, arsenic and antimony. The structures of derived compounds have been solved through XRD and the reactivity behaviour towards selected biomolecules has been investigated through a multi-technique approach involving NMR, high-resolution mass spectrometry and IR. Moreover, the biological activity of the investigated compounds has been comparatively analyzed through classical methodologies and the disclosed differences are discussed in detail.
Topics & Concepts
ChemistryStibineArsineAuranofinPnictogenPhosphineLigand (biochemistry)Reactivity (psychology)AntimonyArsenicStereochemistryCombinatorial chemistryChalcogenComputational chemistryOrganic chemistryReceptorBiochemistryRheumatoid arthritisInternal medicinePhysicsPathologyCatalysisMedicineAlternative medicineSuperconductivityQuantum mechanicsMetal complexes synthesis and propertiesOrganometallic Compounds Synthesis and CharacterizationMetal-Catalyzed Oxygenation Mechanisms