Increased intrinsic default-mode network activity as a compensatory mechanism in aMCI: a resting-state functional connectivity MRI study
Jiali Liang, Yunfei Li, Hao Liu, Sisi Zhang, Meimei Wang, Yonghua Chu, Jianping Ye, Qian Xi, Xiaohu Zhao
Abstract
< 0.05, uncorrected) in the mean FC were found in patients between DN and CN and between DN and AN. Five pairs of FC (false discovery rate corrected) and the Dc of six regions (Bonferroni corrected) displayed a significant increase in patients. Lower cognitive ability was significantly associated with a greater increase in the Dc of the left superior temporal sulcus.Our results demonstrate that the early dysfunctions in aMCI disease are mainly compensatory impairments.
Topics & Concepts
Default mode networkResting state fMRIFunctional magnetic resonance imagingDynamic functional connectivityNeuroscienceFunctional connectivityTask-positive networkCardiologyMagnetic resonance imagingMedicinePsychologyInternal medicineRadiologyFunctional Brain Connectivity StudiesAdvanced Neuroimaging Techniques and ApplicationsNeural dynamics and brain function