Intranasal (R, S)-ketamine delivery induces sustained antidepressant effects associated with changes in cortical balance of excitatory/inhibitory synaptic activity
Thi Mai Loan Nguyen, Céline Defaix, Indira Mendez‐David, Laurent Tritschler, Isabelle Etting, Jean‐Claude Alvarez, Walid Choucha, Romain Colle, Emmanuelle Corruble, Denis J. David, Alain M. Gardier
Topics & Concepts
KetamineMicrodialysisNeurochemicalNMDA receptorGlutamate receptorPharmacologyAntidepressantExcitatory postsynaptic potentialInhibitory postsynaptic potentialPrefrontal cortexChemistryAntagonistNasal administrationAnestheticHippocampusNeuroscienceAnesthesiaMedicineExtracellularEndocrinologyInternal medicineReceptorPsychologyBiochemistryCognitionTreatment of Major DepressionNeuroscience and Neuropharmacology ResearchTryptophan and brain disorders