HDAC6-dependent deacetylation of NGF dictates its ubiquitination and maintains primordial follicle dormancy
Tuo Zhang, Yuntong Tong, Rengguang Zhu, Yao-Yun Liang, Jixian Zhang, Chujiao Hu, Meina He, Zhu Hu, Zhiyi Shen, Jin Niu, Jingjing Zhang, Yuanyuan Yu, Bangming Jin, Shan Lei, Zhirui Zeng, Yingmin Wu, Zengmei Cheng, Ziwen Xiao, Bing Guo, Shuyun Zhao, Guoqiang Xu, Wei Pan, Tengxiang Chen
Abstract
The physiological significance of the high expression of HDAC6 in most primordial follicles is to reduce NGF expression and prevent primordial follicle activation to maintain female fertility. Reduced HDAC6 expression increases NGF expression in primordial follicles, activating their development and contributing to reproduction. Our study provides a clinical reference value for fertility preservation.
Topics & Concepts
UbiquitinAcetylationCell biologyDormancyChemistryHair follicleBiologyBiochemistryBotanyGeneGerminationHistone Deacetylase Inhibitors ResearchSignaling Pathways in DiseaseNuclear Receptors and Signaling