Saliva SARS-CoV-2 Antibody Prevalence in Children
Maya W. Keuning, Marloes Grobben, A Groen, Eveline P. Berman-de Jong, Merijn W. Bijlsma, Sophie Cohen, Mariet Felderhof, Femke de Groof, Daniel Molanus, Nadia Oeij, Maarten Rijpert, Hetty W. M. van Eijk, Gerrit Koen, Karlijn van der Straten, Melissa Oomen, Remco Visser, Federica Linty, Maurice Steenhuis, Gestur Vidarsson, Theo Rispens, Frans B. Plötz, Marit J. van Gils, Dasja Pajkrt
Abstract
Comprehending humoral immunity to SARS-CoV-2, including in children, is crucial for future public health and vaccine strategies. Others have suggested that mucosal antibody measurement could be an important and more convenient tool to evaluate humoral immunity compared to circulating antibodies. Nonetheless, seroprevalence is routinely investigated, while little attention has been paid to mucosal antibodies. We show the heterogeneity of SARS-CoV-2 antibodies, in terms of both antigen specificity and differences between circulating and mucosal antibodies, emphasizing the additional value of saliva antibody detection next to detection of antibodies in serum.