ITGB2-mediated metabolic switch in CAFs promotes OSCC proliferation by oxidation of NADH in mitochondrial oxidative phosphorylation system
Xiaoxin Zhang, Yingchun Dong, Mengxiang Zhao, Liang Ding, Xihu Yang, Yue Jing, Yuxian Song, Sheng Chen, Qingang Hu, Yanhong Ni
Abstract
pro-tumoral CAFs that activated the PI3K/AKT/mTOR axis to promote tumor proliferation in OSCC by NADH oxidation in the mitochondrial oxidative phosphorylation system.
Topics & Concepts
Oxidative phosphorylationCell biologyPhosphorylationMitochondrionChemistryCancer researchBiochemistryBiologyMitochondrial Function and PathologyCancer, Hypoxia, and MetabolismAutophagy in Disease and Therapy