Base‐Catalyzed Synthesis of <i>N</i>‐Aryl Thioacetamides from Multicomponent Reaction of Phenylacetylenes, Sulfur and Anilines
Minh Hang Nguyen, Hai Sam Nguyen, Le Anh Nguyen, Bich Nguyen, Hai Thuong Cao, Dinh Hung Mac, Thanh Bình Nguyễn
Abstract
Abstract In the presence of a base catalyst (20 mol %) such as DBU, DABCO or Na 2 S ⋅ 3H 2 O/ N ‐methylpyrrolidone, phenylacetylenes were found to efficiently undergo sulfurative amination with elemental sulfur and anilines under neat conditions, leading to N ‐aryl thioamides with complete atom efficiency.
Topics & Concepts
ChemistryArylCatalysisSulfurBase (topology)Organic chemistryMedicinal chemistryMathematical analysisAlkylMathematicsSynthesis of heterocyclic compoundsSynthesis and Reactivity of Sulfur-Containing CompoundsSulfur-Based Synthesis Techniques