NecroX-5 alleviate lipopolysaccharide-induced acute respiratory distress syndrome by inhibiting TXNIP/NLRP3 and NF-κB
Xiangzhi Fang, Yali Ge, Zhao-Yuan Chen, Huaqing Shu, Yiyi Yang, Yuan Yu, Xiaojing Zhou, Lin Chen, Shu-Nan Cui, Yaxin Wang, Shanglong Yao, You Shang
Topics & Concepts
TXNIPInflammasomeARDSOxidative stressLipopolysaccharideBronchoalveolar lavageNF-κBMalondialdehydeMyeloperoxidaseDownregulation and upregulationReactive oxygen speciesMedicinePharmacologyInflammationIκBαChemistryImmunologyLungThioredoxinInternal medicineBiochemistryGeneInflammasome and immune disordersHeme Oxygenase-1 and Carbon MonoxideImmune Response and Inflammation