Synthesis and Biological Evaluation of Novel Dispiro Compounds based on 5-Arylidenehydantoins and Isatins as Inhibitors of p53–MDM2 Protein–Protein Interaction
Anastasia A. Beloglazkina, Alexander A. Barashkin, V. S. Polyakov, German Kotovsky, Н.А. Карпов, Sofia Mefedova, Bogdan Zagribelny, Yan A. Ivanenkov, Marina Kalinina, Dmitry A. Skvortsov, В. А. Тафеенко, N. Zyk, Alexander G. Majouga, Елена К. Белоглазкина
Topics & Concepts
ChemistryHydantoinCytotoxicityMdm2P53 proteinIC50Combinatorial chemistryProtein–protein interactionStereochemistryIn vitroCancer cell linesMoleculeCancer cellBiochemistryOrganic chemistryCancerApoptosisInternal medicineMedicineCancer-related Molecular PathwaysClick Chemistry and ApplicationsCancer, Hypoxia, and Metabolism