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Discovery of novel benzimidazole derivatives as potent HDACs inhibitors against leukemia with (Thio)Hydantoin as zinc-binding moiety: Design, synthesis, enzyme inhibition, and cellular mechanistic study

Hanan Gaber Abdulwahab, Reda El‐Sayed Mansour, Thoraya A. Farghaly, Hend M. El‐Sehrawi

2024Bioorganic Chemistry13 citationsDOI

Topics & Concepts

ChemistryBenzimidazoleHydantoinMoietyThio-EnzymeEnzyme inhibitionStereochemistryCombinatorial chemistryZincBiochemistryOrganic chemistryHistone Deacetylase Inhibitors ResearchClick Chemistry and ApplicationsProtein Degradation and Inhibitors
Discovery of novel benzimidazole derivatives as potent HDACs inhibitors against leukemia with (Thio)Hydantoin as zinc-binding moiety: Design, synthesis, enzyme inhibition, and cellular mechanistic study | Litcius