Boosting Chemodynamic Therapy by Tumor-Targeting and Cellular Redox Homeostasis-Disrupting Nanoparticles
Haifeng Lu, Shuxin Xu, Ge Ge, Zhanchen Guo, Menghuan Zhao, Zhen Liu
Abstract
level. As a result, the "maladjusted" tumor cells lost the resistance against •OH damage, finally resulting in the apoptosis of tumor cells. In vitro and in vivo experiments demonstrated that our nanoMIP exhibited excellent cytotoxicity against tumor cells and high efficacy of tumor inhibition in the xenograft tumor model with negligible side effects. Taken together, our study provides not only a promising strategy for maximizing the CDT efficacy but also a new insight for developing MIP-based nanomedicine.
Topics & Concepts
InternalizationTumor microenvironmentIn vivoCytotoxicityCancer researchIn vitroApoptosisChemistryRedoxBiophysicsCell biologyMaterials scienceBiochemistryTumor cellsCellBiologyBiotechnologyOrganic chemistryNanoplatforms for cancer theranosticsAdvanced Nanomaterials in CatalysisNanoparticle-Based Drug Delivery