Structurally divergent enantioselective synthesis of benzofuran fused azocine derivatives and spiro-cyclopentanone benzofurans enabled by sequential catalysis
Rupkumar Khuntia, Sanat Kumar Mahapatra, Lisa Roy, Subhas Chandra Pan
Abstract
) with concomitant epimerization. The skeletally diversified products were formed in high yields with high diastereo- and enantioselectivities. Computational analysis with DFT and accurate DLPNO-CCSD(T) has been employed to gain deeper insights into mechanistic intricacies and investigate the role of chiral and Lewis base catalysts in skeletal diversity.
Topics & Concepts
ChemistryEnantioselective synthesisBenzofuranCyclopentanoneBifunctionalLewis acids and basesAnnulationCatalysisCombinatorial chemistryFrustrated Lewis pairImineOrganic chemistryCatalytic C–H Functionalization MethodsAsymmetric Synthesis and CatalysisChemical Synthesis and Analysis