Photocatalytic Three-Component Assemblies of Enaminones, α-Diazo Esters, and Nitriles for the Synthesis of N,N-Diacylated Glycine Esters
Junlong Zeng, Jie‐Ping Wan, Yunyun Liu
Abstract
A facile method with simple starting materials, including enaminones, α-diazo esters, and nitriles, has been developed for the direct synthesis of N,N -diacyl glycine esters via visible light photocatalysis. The reaction involves a novel carbon–carbon bond cleavage in enaminones, leading to products with high tolerance to the variability of the substructures among all three components.
Topics & Concepts
GlycineDiazoChemistryPhotocatalysisComponent (thermodynamics)Organic chemistryAmino acidBiochemistryCatalysisThermodynamicsPhysicsCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions