Determination and Correlation of the Solubility of <scp>d</scp>(−)-Salicin in Pure and Binary Solvent Systems
Haishuang Huang, Jingxuan Qiu, Hui He, Dengjing Yi, Mengyao An, Haoyou Liu, Shen Hu, Jiaming Han, Ying Guo, Ning Wei, Peng Wang
Abstract
Experimental solubility data of d(−)-salicin in twelve neat solvents (methanol, ethanol, n-propanol, isopropanol, n-butanol, isobutanol, n-pentanol, acetone, acetonitrile, 1,4-dioxance, ethyl acetate, and water) and four binary solvents (water + ethanol, water + acetone, water + isopropanol, and water + methanol) in the temperature range from 283.15 to 323.15 K under atmosphere pressure were determined using the gravimetric method. When the solvent composition was constant, a positive correlation of d(−)-salicin solubility with experimental temperature was found in all investigated pure and mixed solvent systems. At a given temperature, inflection points were found in the solubility curves for binary solvent systems as the mole fraction of water increased, which may be attributed to the cosolvency phenomenon. For the monosolvents, the solubility of d(−)-salicin may be affected by certain factors, such as polarity, steric effects, dipolarity–polarizability, hydrogen bonds, and so on. The KAT-LSER model was used to perform the multiple linear regression analysis on pure and mixed solvent systems to reveal the solute–solvent and solvent–solvent interactions. Finally, the modified Apelblat model, the Jouyban–Acree model, and the Apelblat–Jouyban–Acree model were utilized to correlate the solubility data.