Colibrimycins, Novel Halogenated Hybrid Polyketide Synthase-Nonribosomal Peptide Synthetase (PKS-NRPS) Compounds Produced by <i>Streptomyces</i> sp. Strain CS147
Laura Prado‐Alonso, Ignacio Pérez‐Victoria, Mónica G. Malmierca, Ignacio Montero, Elisa Rioja-Blanco, Jesús Martı́n, Fernando Reyes, Cármen Méndez, José A. Salas, Carlos Olano
Abstract
ant niche. Some colibrimycins display an unusual α-ketoamide moiety in the peptide structure. Although its biosynthetic origin remains unknown, its presence might be related to a hypothetical inhibition of virus proteases, and, together with the presence of the halogenase, it represents a feature to be incorporated in the arsenal of structural modifications available for combinatorial biosynthesis.
Topics & Concepts
Nonribosomal peptidePolyketide synthasePolyketideStreptomycesBiologyStrain (injury)GeneBiochemistryBacteriaBiosynthesisGeneticsAnatomyMicrobial Natural Products and BiosynthesisGenomics and Phylogenetic StudiesMicrobial Metabolism and Applications