The Afirma Xpression Atlas for thyroid nodules and thyroid cancer metastases: Insights to inform clinical decision‐making from a fine‐needle aspiration sample
Jeffrey F. Krane, Edmund S. Cibas, Mayumi Endo, Ellen Marqusee, Mimi I. Hu, Christian Nasr, Steven G. Waguespack, Lori J. Wirth, Richard T. Kloos
Abstract
Recent analytical and clinical validation of the Afirma Xpression Atlas (XA) demonstrates test reliability and the identification of genomic alterations that may inform patient management. The updated Afirma Genomic Sequencing Classifier and XA reports aim to optimize the understanding of these contributions, including decisions about observation versus surgery, the need for disease‐specific preoperative testing, associated neoplasm types, prognostics, the identification of molecular targets for systemic therapy, and the recognition of potential hereditary syndromes.
Topics & Concepts
MedicineThyroid nodulesThyroidThyroid cancerPrognosticsClinical decision makingClassifier (UML)Clinical PracticeOncologyIntensive care medicineBioinformaticsMedical physicsInternal medicinePathologyRadiologyPhysical therapyArtificial intelligenceData miningComputer scienceBiologyThyroid Cancer Diagnosis and TreatmentBRCA gene mutations in cancerGenetic factors in colorectal cancer