Metal-Free Radical-Mediated C(sp<sup>3</sup>)–H Heteroarylation of Alkanes
Xin Shao, Xinxin Wu, Shuo Wu, Chen Zhu
Abstract
Herein we disclose a metal-free, N/O-centered radical-promoted Minisci reaction, in which the coupling of various heteroarenes with simple alkanes proceeds under mild conditions. The reaction conditions are neutral; no extra acid is added to preactivate N-heteroarenes in the Minisci reaction. The N-/O-centered radicals are generated directly from amide (TsNHMe) or alcohol (CF3CH2OH) under visible-light irradiation. This green and eco-friendly synthetic process may find potential use in medicinal chemistry.
Topics & Concepts
ChemistryRadicalAmideMetalAlcoholCoupling reactionPhotochemistryCombinatorial chemistryMedicinal chemistryOrganic chemistryCatalysisRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques