Tumor-activated targetable photothermal chemotherapy using IR780/zoledronic acid-containing hybrid polymeric nanoassemblies with folate modification to treat aggressive breast cancer
Yuling Liu, Tzu-Hao Wang, Nien-Tzu Yeh, Wei-Jen Huang, Bor‐Show Tzang, I‐Ting Wu, Hao-Yang Chin, Shang‐Hsiu Hu, Tsai‐Ching Hsu, Wen‐Hsuan Chiang
Abstract
studies demonstrated that the FA-ZA/IR780@HPNs largely deposited at 4T1 tumor sites and profoundly suppressed tumor growth and metastasis without severe systemic toxicity upon near infrared (NIR)-triggered IR780-mediated hyperthermia integrated with ZA chemotherapy. This work presents a practical strategy to treat aggressive breast tumors with tumor-triggered targetable photothermal chemotherapy using FA-ZA/IR780@HPNs.
Topics & Concepts
Photothermal therapyZoledronic acidChemotherapyBreast cancerFolic acidCancerCancer researchMedicineOncologyMaterials scienceNanotechnologyInternal medicineNanoplatforms for cancer theranosticsNanoparticle-Based Drug DeliveryAdvanced Nanomaterials in Catalysis