Dissecting Individual Interactions between Pathogenic and Commensal Bacteria within a Multispecies Gut Microbial Community
Jack Hassall, Jeffrey K. J. Cheng, Meera Unnikrishnan
Abstract
Studying interactions between bacterial species that reside in the human gut is crucial for gaining a better insight into how they provide protection from pathogen colonization. In vitro models of multispecies bacterial communities wherein behaviors of single species can be accurately tracked are key to such studies. Here, we have developed a synthetic, trackable, gut microbiota community which reduces growth of the human gut pathogen Clostridioides difficile .
Topics & Concepts
BiologyBacteroidesMicrobiologyClostridioidesPathogenColonizationCommensalismBiofilmBacteroides fragilisColonisation resistanceGut floraBacteroides thetaiotaomicronIn vitroBacteriaHuman pathogenImmunologyAntibioticsGeneticsClostridium difficile and Clostridium perfringens researchGut microbiota and healthProbiotics and Fermented Foods